Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-

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Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- Basic information
Product Name:Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-
Synonyms:Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;EGFR-IN-117
CAS:3035639-05-2
MF:C25H30BrN7O2S
MW:572.52
EINECS:
Product Categories:
Mol File:3035639-05-2.mol
Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- Structure
Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- Chemical Properties
Boiling point 719.9±70.0 °C(predicted)
density 1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.02±0.20(predicted)
Safety Information
MSDS Information
Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- Usage And Synthesis
UsesEGFR-IN-117 (Compound 8h) exhibits inhibitory activity against EGFR mutation, targets the tumor environment, and induces apoptosis of cancer cells. EGFR-IN-117 inhibits proliferations of H1975, PC-9, and EGFR mutant cells BaF3-EGFRL858R/T790M/C797S and BaF3–C797S/Del19/T790M, with IC50 of 13 nM, 19 nM, 1.2 nM and 1.3 nM, respectively. EGFR-IN-117 exhibits antitumor efficacy in mouse models[1].
References[1] Yao H, et al., Discovery of new cyclopropane sulfonamide derivatives as EGFR inhibitors to overcome C797S-mediated resistance and EGFR double mutation. Eur J Med Chem. 2024 Jun 16;275:116590. DOI:10.1016/j.ejmech.2024.116590
Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]- Preparation Products And Raw materials
Tag:Cyclopropanesulfonamide, N-[2-[[5-bromo-2-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-(3035639-05-2) Related Product Information
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