莪术呋喃二烯酮
| 中文名称 | 莪术呋喃二烯酮 |
|---|---|
| 中文同义词 | 莪术环二烯酮;呋喃二烯酮;莪术呋喃二烯酮;莪术呋喃二烯酮标准品;莪术呋喃二烯酮对照品;呋喃二烯酮,蓬莪术环二烯酮;(5E,9E)-3,6,10-三甲基-7,8-二氢环癸[B]呋喃-4(11H)-酮;(5E,9E)-8,11-二氢-3,6,10-三甲基环癸并[B]呋喃-4(7H)-酮 |
| 英文名称 | Furanodienone |
| 英文同义词 | Furanodienone;(5E,9E)-8,11-Dihydro-3,6,10-trimethylcyclodeca[b]furan-4(7H)-one;(1E,4E)-8,12-Epoxygermacra-1(10),4,7,11-tetraen-6-one;Cyclodeca[b]furan-4(7H)-one, 8,11-dihydro-3,6,10-trimethyl-, (5E,9E)-;(5Z)-3,6,10-trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-one;(5Z)-3,6,10-trimethyl-8,11-dihydrocyclodeca[b]furan-4(7H)-on...;(5E,9E)-3,6,10-Trimethyl-7,8-dihydrocyclodeca[b]furan-4(11H)-one;Furanodienone, 10 mM in DMSO |
| CAS号 | 24268-41-5 |
| 分子式 | C15H18O2 |
| 分子量 | 230.3 |
| EINECS号 | |
| 相关类别 | 植物提取物;标准品;对照品;中药对照品;对照品-中药对照品;标准品 -中药标准品 |
| Mol文件 | 24268-41-5.mol |
| 结构式 |  |
莪术呋喃二烯酮 性质
| 熔点 | 83-84℃ |
|---|---|
| 沸点 | 89.5-90.5 °C |
| 密度 | 1.022±0.06 g/cm3(Predicted) |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| LogP | 2.654 (est) |
Furanodienone (0-573.8 μM; 24 hours) exhibits IC 50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively. Furanodienone (0-150 μM; 24 hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells. Furanodienone (0-150 μM; 24 hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%.
Western Blot Analysis
| Cell Line: | RKO and HT-29 cells |
| Concentration: | 0 μM; 50 μM; 100 μM; 150 μM |
| Incubation Time: | 24 hours |
| Result: | Increased caspase-9 and -3. |
Apoptosis Analysis
| Cell Line: | RKO and HT-29 cells |
| Concentration: | 0 μM; 75 μM; 150 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis of colorectal cells (RKO and HT-29). |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N2184 | 莪术呋喃二烯酮 Furanodienone | 24268-41-5 | 1 mg | 571元 |
| 2026/06/05 | HY-N2184 | 莪术呋喃二烯酮 Furanodienone | 24268-41-5 | 5mg | 1500元 |