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| | 2-PYRIMIDINEMETHANAMINE Basic information |
| | 2-PYRIMIDINEMETHANAMINE Chemical Properties |
| Boiling point | 179.922±23.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.138±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Oil | | pka | 7.817±0.29(predicted) | | color | Pale Yellow to Dark Yellow |
| | 2-PYRIMIDINEMETHANAMINE Usage And Synthesis |
| Chemical Properties | white powder | | Uses | 2-Pyrimidinemethanamine can be prepared to combat abiotic plant stress. | | Synthesis | General procedure for the synthesis of 2-methylaminopyrimidine from 2-cyanopyrimidine: To a stirred solution of 2-cyanopyrimidine (10) (0.2 g, 0.9 mmol) in ethanol (1 mL) was added 10% palladium/carbon (20 mg) under a nitrogen atmosphere. The reaction mixture was stirred under hydrogen atmosphere (using a balloon to maintain atmospheric pressure) for 12 h. Upon completion of the reaction, it was filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by neutral alumina column chromatography (eluent: ethyl acetate/hexane = 1:1) to afford 2-methylaminopyrimidine (24) (0.19 g, 95% yield). Thin layer chromatography (TLC) conditions: 50% ethyl acetate/hexane (Rf: 0.1). 1H NMR (400 MHz, CDCl3): δ 8.70 (d, J=5.2 Hz, 2H), 7.16 (t, J=4.8 Hz, 1H), 4.19 (s, 1H), 4.11-4.08 (m, 1H). | | References | [1] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 42
[2] Patent: WO2014/120783, 2014, A1. Location in patent: Paragraph 00143
[3] Patent: US5312823, 1994, A |
| | 2-PYRIMIDINEMETHANAMINE Preparation Products And Raw materials |
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