4-Amino-5-aminomethyl-2-methylpyrimidine manufacturers
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| | 4-Amino-5-aminomethyl-2-methylpyrimidine Basic information |
| | 4-Amino-5-aminomethyl-2-methylpyrimidine Chemical Properties |
| Melting point | 270-272°C | | Boiling point | 121-125 °C | | density | 1.207 | | vapor pressure | 0.012-0.019Pa at 20-25℃ | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) | | form | Solid | | pka | 7.70±0.29(Predicted) | | color | Off-White to Beige | | PH | 10.65 at 20℃ and 10g/L | | InChI | InChI=1S/C6H10N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,2,7H2,1H3,(H2,8,9,10) | | InChIKey | OZOHTVFCSKFMLL-UHFFFAOYSA-N | | SMILES | C1(C)=NC=C(CN)C(N)=N1 | | LogP | -2.27 at 20℃ and pH7 | | Surface tension | 72.77mN/m at 1g/L and 20℃ |
| | 4-Amino-5-aminomethyl-2-methylpyrimidine Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | Substrate for TenA enzyme in the thiamin salvage pathway | | Definition | ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively. | | Synthesis |
In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].
| | References |
[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.
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| | 4-Amino-5-aminomethyl-2-methylpyrimidine Preparation Products And Raw materials |
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