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| | T-10418 Basic information |
| Product Name: | T-10418 | | Synonyms: | T-10418;D-Phenylalanine, N-[3-(3-pyridinylmethoxy)benzoyl]- | | CAS: | 1608784-68-4 | | MF: | C22H20N2O4 | | MW: | 376.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1608784-68-4.mol |  |
| | T-10418 Chemical Properties |
| Boiling point | 631.856±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.270±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 3.746±0.10(predicted) | | form | Solid | | color | White to off-white |
| | T-10418 Usage And Synthesis |
| Uses | T-10418 is an agonist for G2 accumulation protein (G2A) (also known as G protein-coupled receptor GPR132) with an EC50 of 0.82 μM. T-10418 exhibits a sensitizing effect on mouse primary sensory neurons. T-10418 exhibits good pharmacokinetic characteristics, and no obvious toxicity (at 100 μM) in mouse models[1]. | | References | [1] Hernandez-Olmos V, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 2024 Jun 25. DOI:10.1021/acs.jmedchem.3c02164 |
| | T-10418 Preparation Products And Raw materials |
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