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| | Dexamethasone sodium phosphate Basic information |
| Product Name: | Dexamethasone sodium phosphate | | Synonyms: | DEXAMETHASONE SODIUM PHOSPHATE;DEXAMETHASONE PHOSPHATE SODIUM;DEXAMETHASONE PHOSPHATE DISODIUM SALT;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11β,16α)-;Dexamethasone sodium phosphate USP/EP/BP;Veterinary Medicine D Examethasone CAS 55203-24-2 | | CAS: | 55203-24-2 | | MF: | C22H28FNa2O8P | | MW: | 516.4 | | EINECS: | 219-243-0 | | Product Categories: | Inhibitors;55203-24-2 | | Mol File: | 55203-24-2.mol |  |
| | Dexamethasone sodium phosphate Chemical Properties |
| | Dexamethasone sodium phosphate Usage And Synthesis |
| Uses | Dexamethasone Sodium Phosphate is an inducer of apoptosis and inhibitor of the sodium phosphate symporter. | | Definition | ChEBI: Dexamethasone sodium phosphate is an organic sodium salt which is the disodium salt of dexamethasone phosphate. It has a role as a glucocorticoid receptor agonist. It contains a dexamethasone phosphate(2-). | | Brand name | Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon). | | Synthesis | Preparation of dexamethasone sodium phosphate for injection. Synthesis: Using dexamethasone acetate epoxide as the starting material, steps include a ring-opening reaction (HF/DMF, -10C), recrystallization (methanol), base-catalyzed hydrolysis (Na2CO3/methanol, 20C), esterification with pyrophosphoryl chloride (THF), and neutralization/salt formation (NaOH/methanol, 20C) to yield a dexamethasone sodium phosphate solution, which is recrystallized again to give crystals. The crystals are dried and ball-milled, then mixed with glucose, disodium hydrogen phosphate, and sodium dihydrogen phosphate. This mixture is dissolved in water for injection, ethanol and activated carbon are added, the solution is kept warm, and then filtered. |
| | Dexamethasone sodium phosphate Preparation Products And Raw materials |
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