SDZ 220-581 manufacturers
- SDZ 220-581
-
- $30.00
-
2026-05-11
- CAS:174575-17-8
- Purity:
- Supply Ability: 10g
- SDZ 220-581
-
- $73.00
-
2025-10-28
- CAS:174575-17-8
- Purity:
- Supply Ability: 10g
|
| | SDZ 220-581 Basic information |
| Product Name: | SDZ 220-581 | | Synonyms: | (S)-ALPHA-AMINO-2'-CHLORO-5-(PHOSPHONOMETHYL)[1,1'-BIPHENYL]-3-PROPANOIC ACID;SDZ 220-581;alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid;(S)-α-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoicacid;[1,1'-Biphenyl]-3-propanoic acid, α-amino-2'-chloro-5-(phosphonomethyl)-, (αS)-;SDZ 220581,SDZ 220 581 | | CAS: | 174575-17-8 | | MF: | C16H17ClNO5P | | MW: | 369.74 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 174575-17-8.mol |  |
| | SDZ 220-581 Chemical Properties |
| Boiling point | 613.3±65.0 °C(Predicted) | | density | 1.478 | | storage temp. | Store at RT | | solubility | DMSO : 8.57 mg/mL (23.18 mM; Need ultrasonic and warming) | | form | Powder | | pka | 1.63±0.10(Predicted) | | color | Light yellow to yellow |
| | SDZ 220-581 Usage And Synthesis |
| Uses | SDZ 220-581 is a competitive NMDA receptor antagonist. | | Biological Activity | Competitive NMDA receptor antagonist (pK i = 7.7). Centrally active following oral administration (ED 50 < 3.2 mg/kg for protection against MES-induced seizures). | | in vivo | SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1]. | Animal Model: | Male OF-l mice (18-26 g)[1] | | Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg | | Administration: | Oral administration; for 24 hours | | Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
|
| | IC 50 | NMDA Receptor | | storage | Store at RT |
| | SDZ 220-581 Preparation Products And Raw materials |
|