5,12-dihydroquinoxalino[2,3-b]quinoxaline

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5,12-dihydroquinoxalino[2,3-b]quinoxaline manufacturers

  • ML-090
  • ML-090 pictures
  • $29.00
  • 2026-07-14
  • CAS:531-46-4
  • Purity: 98.55%
  • Supply Ability: 10g
5,12-dihydroquinoxalino[2,3-b]quinoxaline Basic information
Product Name:5,12-dihydroquinoxalino[2,3-b]quinoxaline
Synonyms:5,12-dihydroquinoxalino[2,3-b]quinoxaline;ML-090;6,11-dihydroquinoxalino[2,3-b]quinoxaline;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1;Fluoflavine
CAS:531-46-4
MF:C14H10N4
MW:234.26
EINECS:
Product Categories:
Mol File:531-46-4.mol
5,12-dihydroquinoxalino[2,3-b]quinoxaline Structure
5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemical Properties
Melting point >262°C (dec.)
Boiling point 450.2±28.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly, Heated, Sonicated)
form Solid
pka3.94±0.20(Predicted)
color Off-White to Dark Yellow
InChIInChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)
InChIKeyWGKYYZDYHYOKQV-UHFFFAOYSA-N
SMILESN1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3
Safety Information
MSDS Information
5,12-dihydroquinoxalino[2,3-b]quinoxaline Usage And Synthesis
DescriptionNADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 μM) and xanthine oxidase (IC50 = 3.5 μM).
Uses5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor ofNADPH oxidase 1 (NOX1).
DefinitionChEBI: 6,11-dihydroquinoxalino[2,3-b]quinoxaline is a quinoxaline derivative.
IC 50NOX1
References[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
5,12-dihydroquinoxalino[2,3-b]quinoxaline Preparation Products And Raw materials
Tag:5,12-dihydroquinoxalino[2,3-b]quinoxaline(531-46-4) Related Product Information
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