| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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| Tel: |
0717-6449896 13886658719 |
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root@zhongyitai.com |
| Products Intro: |
Product Name:12-hydroxy-5(Z),8(Z),10(E),14(Z)-Eicosatetraenoic acid
CAS:71030-37-0
Purity:98+% Package:100ug
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| Company Name: |
Alfa Chemistry
|
| Tel: |
1-516-6625404 |
| Email: |
support@alfa-chemistry.com |
| Products Intro: |
Product Name:12-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid
CAS:71030-37-0
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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(+/-)12-HETE manufacturers
- 12-HETE
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- $925.00
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2026-05-11
- CAS:71030-37-0
- Purity:
- Supply Ability: 10g
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| | (+/-)12-HETE Basic information |
| Product Name: | (+/-)12-HETE | | Synonyms: | (+/-)12-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;(+/-)12-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;(+/-)12-HETE;10,14-eicosatetraenoicacid,12-hydroxy-,(e,z,z,z)-8;12-hydroxyeicosatetraenoicacid;(5E,8Z,10Z,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid;(5Z,8Z,10E,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid;(5Z,8Z,10E,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid | | CAS: | 71030-37-0 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 71030-37-0.mol |  |
| | (+/-)12-HETE Chemical Properties |
| Boiling point | 487.7±45.0 °C(Predicted) | | density | 0.984±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml | | form | Liquid | | pka | 4.75±0.10(Predicted) | | color | Colorless to light yellow |
| | (+/-)12-HETE Usage And Synthesis |
| Description | (±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC50 value of 40 nM. | | Uses | 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3]. | | Definition | ChEBI: (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid is the (5Z,8Z,10E,14Z)-stereoisomer of 12-HETE. It has a role as a mouse metabolite. It is a conjugate acid of a 12-HETE(1-). | | References | [1] Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838. DOI:10.2147/CMAR.S180334
[2] Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40. DOI:10.1016/j.jchromb.2014.03.015
[3] Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64. DOI:10.1523/JNEUROSCI.22-01-00257.2002 |
| | (+/-)12-HETE Preparation Products And Raw materials |
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