1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	Chengdu YouSuo Biotechnology Limited
Tel:	13693449011
Email:	83948782@qq.com

Company Name:	Shanghai Lollane Biological Technology Co.,Ltd.
Tel:	021-52996696，15000506266 15000506266
Email:

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride manufacturers

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride Basic information

Product Name:	1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride
Synonyms:	RS 67333 HYDROCHLORIDE;RS67333HCl;1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride;1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1);RS 67333 hydrochloride >=98% (HPLC);RS 67333 hydrochlori;RS 67333 hydrochloride, 10 mM in DMSO;1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride
CAS:	168986-60-5
MF:	C19H30Cl2N2O2
MW:	389.36
EINECS:
Product Categories:
Mol File:	168986-60-5.mol

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride Chemical Properties

storage temp.	Store at RT
solubility	H₂O: 1 mg/mL, clear (warmed)
form	Powder
color	Light yellow to yellow
Water Solubility	Soluble to 25 mM in water with gentle warming
InChI	1S/C19H29ClN2O2.ClH/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2;/h12-14H,3-11,21H2,1-2H3;1H
InChIKey	XVBGLZNYWUUAFF-UHFFFAOYSA-N
SMILES	O=C(C1=CC(Cl)=C(N)C=C1OC)CCC2CCN(CCCC)CC2.[H]Cl

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

MSDS Information

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride Usage And Synthesis

Uses	RS 67333 Hydrochloride is a 5-HT4 receptor agonist.
Biological Activity	A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.
Biochem/physiol Actions	RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).
IC 50	5-HT₄ Receptor: 8.7 (pKi)

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride Preparation Products And Raw materials

Tag:1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride(168986-60-5) Related Product Information

Poly(hexamethylenebiguanide)hydrochloride Triethylamine hydrochloride 1-(4-Amino-3-chloro-phenyl)-propan-1-one 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride 1-(4-Amino-3-chloro-phenyl)-ethanone 4-(3-Phenyl-propyl)-piperidine HCl p-Hexylaniline hydrochloride 1-(4-Amino-2-hydroxy-phenyl)-propan-1-one 2-Chloro-5-methoxyaniline 4-aminohexanoylphenone