|
|
| | 5-Amino-1-methylpyrazole-4-carboxamide Basic information |
| Product Name: | 5-Amino-1-methylpyrazole-4-carboxamide | | Synonyms: | 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXAMIDE;5-AMINO-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE;5-AMINO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID AMIDE;BUTTPARK 94\04-11;5-Amino-1,3-dimethyl-1H-pyrazole-4-carboxamide;5-Amino-1-methylpyrazole-4-carboxamide, tech;5-Amino-1-methyl-1h-pyrazole-4-carboxamide, tech;1H-Pyrazole-4-carboxamide,5-amino-1-methyl-(9CI) | | CAS: | 18213-75-7 | | MF: | C5H8N4O | | MW: | 140.14 | | EINECS: | 200-258-5 | | Product Categories: | Miscellaneous;AMIDE | | Mol File: | 18213-75-7.mol |  |
| | 5-Amino-1-methylpyrazole-4-carboxamide Chemical Properties |
| Melting point | 224-226°C | | Boiling point | 355.1±22.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 15.26±0.50(Predicted) |
| | 5-Amino-1-methylpyrazole-4-carboxamide Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 5-amino-1-methyl-1H-pyrazole-4-carboxamide from 1-methyl-4-cyano-5-amino-1,2-pyrazole was carried out as follows: a mixture of 1-methyl-4-cyano-5-amino-1,2-pyrazole (0.11 mol) and concentrated sulfuric acid (30 mL, 0.6 mol) was stirred for 1 h at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to 8 with 50% aqueous ammonium hydroxide under ice bath conditions.Subsequently, the precipitated solid product was filtered and washed with cold water to give the final 5-amino-1-methyl-1H-pyrazole-4-carboxamide (13.5 g, 91% yield). | | References | [1] Patent: WO2009/97446, 2009, A1. Location in patent: Page/Page column 64
[2] Journal of Organic Chemistry, 1956, vol. 21, p. 1240,1242
[3] Patent: EP2025678, 2009, A1. Location in patent: Page/Page column 18-19 |
| | 5-Amino-1-methylpyrazole-4-carboxamide Preparation Products And Raw materials |
|