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| | 2-(TRIBUTYLSTANNYL)THIAZOLE Basic information |
| | 2-(TRIBUTYLSTANNYL)THIAZOLE Chemical Properties |
| Melting point | 224-225℃ | | Boiling point | 307-309 °C(lit.) | | density | 1.1900 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.5200(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,2-8°C | | solubility | Not miscible or difficult to mix. | | pka | 2.73±0.10(Predicted) | | form | liquid | | color | Clear, almost colourless | | InChI | InChI=1S/3C4H9.C3H2NS.Sn/c3*1-3-4-2;1-2-5-3-4-1;/h3*1,3-4H2,2H3;1-2H; | | InChIKey | WUOFQGMXQCSPPV-UHFFFAOYSA-N | | SMILES | S1C=CN=C1[Sn](CCCC)(CCCC)CCCC |
| Hazard Codes | T,N,Xi | | Risk Statements | 21-25-36/38-48/23/25-50/53 | | Safety Statements | 35-36/37/39-45-60-61 | | RIDADR | UN 2788 6.1/PG 2 | | WGK Germany | 3 | | HazardClass | IRRITANT, KEEP COLD, TOXIC | | HazardClass | 6.1 | | HS Code | 2934100090 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 3 Oral
Acute Tox. 4 Dermal
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Repr. 1B
Skin Irrit. 2
STOT RE 1 |
| | 2-(TRIBUTYLSTANNYL)THIAZOLE Usage And Synthesis |
| Uses | Reagent for arylation of thiazole by Stille cross-coupling.1 | | Uses | Used as reagent for arylation of thiazole by Stille cross-coupling. | | Synthesis | A hexane solution of n-butyllithium (6.14 mmol, 2.5 M) was slowly added dropwise to a stirred anhydrous ethyl ether solution of 2-bromothiazole (3.07 mmol) at 0 °C under argon protection. After 1 hour of reaction, the mixture was cooled to -78 °C, followed by the slow addition of anhydrous ether solution of tributyltin chloride (3.07 mmol). The mixture was stirred at -78°C overnight. After completion of the reaction, the mixture was poured into water (50 mL) and the aqueous layer was extracted with ether (3 x 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 2-(tri-n-butylmethylstannyl)thiazole (L-01b) as a light brown oil in quantitative yield. The product was used directly for the synthesis of the subsequent compound L-01a without further purification. | | References | [1] Patent: US8575355, 2013, B2. Location in patent: Paragraph 0032
[2] Patent: JP2016/56276, 2016, A. Location in patent: Paragraph 0129; 0130
[3] Patent: KR2017/26286, 2017, A. Location in patent: Paragraph 0112-0115
[4] Patent: EP1982982, 2008, A1. Location in patent: Page/Page column 76
[5] Patent: KR101511396, 2015, B1. Location in patent: Paragraph 1061-1064 |
| | 2-(TRIBUTYLSTANNYL)THIAZOLE Preparation Products And Raw materials |
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