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| | 4-Methoxy-3-nitro-benzeneacetic acid methyl ester Basic information |
| Product Name: | 4-Methoxy-3-nitro-benzeneacetic acid methyl ester | | Synonyms: | BENZENEACETIC ACID, 4-METHOXY-3-NITRO-, METHYL ESTER;Methyl 2-(4-methoxy-3-nitrophenyl);2-(4-METHOXY-3-NITRO PHENYL) ACETIC ACID METHYL ETSER;Methyl 2-(4-methoxy-3-nitrophenyl)acetate;4-Methoxy-3-nitro-benzeneacetic acid methyl ester | | CAS: | 34837-88-2 | | MF: | C10H11NO5 | | MW: | 225.2 | | EINECS: | | | Product Categories: | | | Mol File: | 34837-88-2.mol |  |
| | 4-Methoxy-3-nitro-benzeneacetic acid methyl ester Chemical Properties |
| Melting point | 100-102° | | Boiling point | 356.8±27.0 °C(Predicted) | | density | 1.264±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | 4-Methoxy-3-nitro-benzeneacetic acid methyl ester Usage And Synthesis |
| Synthesis | General procedure for the synthesis of methyl 2-(4-methoxy-3-nitrophenyl)acetate from methyl 2-(4-hydroxy-3-nitrophenyl)acetate and iodomethane: To a solution of methyl 2-(4-hydroxy-3-nitrophenyl)acetate (4.87 g, 23.1 mmol) was added K2CO3 (8 g, 58 mmol) at room temperature, followed by slow addition of CH3I ( 6.6 g, 46.5 mmol). The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the mixture was poured into ice water (100 mL) and extracted with CH2Cl2 (3 x 300 mL). The organic layers were combined, washed with brine, dried over Na2SO4, filtered and concentrated to give methyl 2-(4-methoxy-3-nitrophenyl)acetate (5 g, 96% yield) as a yellow solid.LCMS analysis showed an [M + H]+ of 226.0; retention time (Rt) of 1.438 min. | | References | [1] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 106; 107 |
| | 4-Methoxy-3-nitro-benzeneacetic acid methyl ester Preparation Products And Raw materials |
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