Frakefamide

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Frakefamide Suppliers list
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Beijing HuaMeiHuLiBiological Chemical   
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Email: waley188@sohu.com
Company Name: TargetMol Chemicals Inc.  
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Company Name: Suzhou Meishi Biotechnology Co., Ltd.  
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Email: meishipharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn

Frakefamide manufacturers

  • Frakefamide
  • Frakefamide pictures
  • $2580.00
  • 2026-05-11
  • CAS:188196-22-7
  • Purity:
  • Supply Ability: 10g
  • Frakefamide
  • Frakefamide pictures
  • $2580.00
  • 2025-08-22
  • CAS:188196-22-7
  • Purity:
  • Supply Ability: 10g
Frakefamide Basic information
Product Name:Frakefamide
Synonyms:L-Tyrosyl-D-alanyl-L-(4-fluoro)phenylalanyl-L-phenylalanylamide;L-Phenylalaninamide, L-tyrosyl-D-alanyl-4-fluoro-L-phenylalanyl-;Frakefamide
CAS:188196-22-7
MF:C30H34FN5O5
MW:563.62
EINECS:
Product Categories:
Mol File:188196-22-7.mol
Frakefamide Structure
Frakefamide Chemical Properties
Boiling point 973.0±65.0 °C(Predicted)
density 1.295±0.06 g/cm3(Predicted)
pka9.97±0.15(Predicted)
SequenceTyr-Ala-Phe(4-F)-Phe-NH2
Safety Information
MSDS Information
Frakefamide Usage And Synthesis
UsesFrakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2].
in vivo

Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].

References[1] Modalen AO, et al. A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7. DOI:10.1213/01.ANE.0000145011.75545.C5
[2] Swedberg MD, et al. Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuse. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:295-305. DOI:10.1016/j.vascn.2016.05.011
Frakefamide Preparation Products And Raw materials
Tag:Frakefamide(188196-22-7) Related Product Information
Frakefamide (Phe4)-dermorphin (1-4) amide 3-Amino-1-(4-fluoro-benzyl)-4-(3-methoxy-phenyl)-azetidin-2-one Bz-Tyr-NH2 Philanthotoxin 74 Ac-Val-Tyr-Lys-NH2