1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride manufacturers

1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Basic information

Product Name:	1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
Synonyms:	DPPI 1C HYDROCHLORIDE;DPPI 1C HCL;Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem;2,5-Pyrrolidinedicarbonitrile, 1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-, (2R,5S)-rel-;1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
CAS:	866396-34-1
MF:	C14H20N4O2
MW:	276.33
EINECS:
Product Categories:
Mol File:	866396-34-1.mol

1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Chemical Properties

Boiling point	567.631±50.00 °C(Press: 760.00 Torr)(predicted)
density	1.257±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	Desiccate at RT
solubility	Soluble in DMSO > 10 mM
form	White solid
pka	15.049±0.10(predicted)
color	white
Water Solubility	PBS: 20mg/mL ethanol: 20mg/mL water: 20mg/mL

Safety Information

WGK Germany	WGK 2
Storage Class	11 - Combustible Solids

MSDS Information

1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Usage And Synthesis

Uses	DPP4-In is an active compound.
General Description	An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC₅₀ = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
Biological Activity	Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC 50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC 50 > 30 μ M). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.
References	[1] High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes

1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Preparation Products And Raw materials

Tag:1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride(866396-34-1) Related Product Information

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