1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- manufacturers
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| | 1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- Basic information |
| | 1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- Chemical Properties |
| Boiling point | 504.9±50.0 °C(Predicted) | | density | 1.190±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 50 mg/mL (170.44 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 7.53±0.50(Predicted) | | color | Light yellow to yellow |
| | 1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- Usage And Synthesis |
| Uses | 3-arylisoquinolinamine derivative is a 3-arylisoquinolinamine derivative with antitumor activity. | | in vivo | 3-arylisoquinolinamine derivative (Compound 13) has higher antitumor efficacy (69.2 % inhibition) than that of the control drug, Paclitaxel (48.8 % inhibition) in the inhibition of growth of tumor in an animal model[2]. | | References | [1] Yang SH, et al. Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5277-81. DOI:10.1016/j.bmcl.2010.06.132
[2] Young Bok Lee, et al. 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents. WO 2008063548 A2. |
| | 1,7-Isoquinolinediamine, 3-(3-methoxyphenyl)-N7,N7-dimethyl- Preparation Products And Raw materials |
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