N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride

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N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride manufacturers
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride Basic information
Product Name:N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride
Synonyms:LY 2365109;LY-2365109;LY 2365109 hydrochloride;N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride;LY2365109;Glycine, N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-;Ly 2365109 Hydrochloride,n-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-n-methylglycinehydrochloride
CAS:868265-28-5
MF:C22H27NO5
MW:385.45
EINECS:
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Mol File:868265-28-5.mol
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride Structure
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride Chemical Properties
Boiling point 556.2±50.0 °C(Predicted)
density 1.187±0.06 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol
form Powder
pka2.27±0.10(Predicted)
InChIInChI=1S/C22H27NO5/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25)
InChIKeyFKPLJWGRBCQLTL-UHFFFAOYSA-N
SMILESC(O)(=O)CN(CCOC1=CC=C(C2=CC=C3OCOC3=C2)C=C1C(C)(C)C)C
Safety Information
MSDS Information
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride Usage And Synthesis
UsesLY 2365109 Hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor.
in vivo

LY2365109 (0.3-30 mg/kg; p.o.) produces dose-dependent elevations of Sprague–Dawley rats in CSF levels of glycine[1].

N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride Preparation Products And Raw materials
Tag:N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride(868265-28-5) Related Product Information
N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycinehydrochloride LY2365109 (hydrochloride) L-ANTI-ENDO-3,4-METHANOPYRROLIDINEDICARBOXYLIC ACID 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole [4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-Methylsulfonyl-2-[((S)-2,2,2-trifluoro-1-methylethyl)oxy]phenyl]methanone [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[(1R,5R)-1-(5-trifluoromethyl-isoxazol-3-yl)-3-aza-bicyclo[3.1.0]