2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester

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2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Basic information
Product Name:2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester
Synonyms:ART-CHEM-BB B000469;AURORA 12174;AKOS BBS-00000802;AKOS B000469;OTAVA-BB BB7111630001;TIMTEC-BB SBB001044;Methyl 2-amino-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate;AK-968/37129027
CAS:213192-26-8
MF:C14H21NO2S
MW:267.39
EINECS:
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Mol File:Mol File
2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Structure
2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Chemical Properties
Melting point 120-125°C
Safety Information
Hazard Codes Xi
HazardClass IRRITANT
MSDS Information
2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Usage And Synthesis
UsesTBTC is a selective agonist with the activity of improving behavioral deficits in Alzheimer's disease model mice. TBTC can effectively activate the heterodimerization of RXRα with LXRα or PPARγ. TBTC stimulates the expression of apoE, ABCA1, and ABCG1 genes and reduces Aβ content in cells and animal models[1].
References[1] Small molecule TBTC as a new selective retinoid X receptor α agonist improves behavioral deficit in Alzheimer's disease model mice
2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materialsMethyl cyanoacetate-->4-tert-Butylcyclohexanone
Tag:2-Amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid methyl ester(213192-26-8) Related Product Information
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