PF 4800567
| 中文名称 | PF 4800567 |
|---|---|
| 中文同义词 | 3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺;PF-4800567游离态;化合物PF-4800567;3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑啉[3,4-D]嘧啶-4-胺;化合物PF-4800567,10 MM DMSO 溶液;PF-4800567 |CAS 1188296-52-7;抑制剂PF-4800567;抑制剂PF-4800567 |
| 英文名称 | PF 4800567 hydrochloride |
| 英文同义词 | 3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride;PF 4800567;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PF 4800567 hydrochloride;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine;PF 4800567;PF-4800567;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-;Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor |
| CAS号 | 1188296-52-7 |
| 分子式 | C17H18ClN5O2 |
| 分子量 | 359.81 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1188296-52-7.mol |
| 结构式 |  |
PF 4800567 性质
| 沸点 | 592.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMF：25mg/mL； DMF:PBS(pH 7.2)(1:1)：0.5 mg/ml； DMSO：10mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.01±0.30(Predicted) |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) |
| InChIKey | AUMDBEHGJRZSOO-UHFFFAOYSA-N |
| SMILES | NC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4 |
| Target | Value |
|
casein kinase 1 epsilon
(Cell-free assay) | 32 nM |
|
casein kinase 1 delta
() | 711 nM |
PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC 50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC 50 , 711 nM). PF-4800567 shows inhibitory activity against CK1ϵ and CK1δ in whole cells, with IC 50 s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ϵ-mediated PER3 nuclear localization mediated by CK1ϵ and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
PF 4800567 is a selective casein kinase inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S2249 | 3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF 4800567 | 1188296-52-7 | 5mg | 930.64元 |
| 2026/06/05 | HY-12470 | PF-4800567 | 1188296-52-7 | 1 mg | 192元 |