| Company Name: |
BOC Sciences |
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
2-Guanidinoethylmercaptosuccinic acid manufacturers
- GEMSA
-
- $663.00
-
2026-07-27
- CAS:77482-44-1
- Purity:
- Supply Ability: 10g
|
| | 2-Guanidinoethylmercaptosuccinic acid Basic information |
| Product Name: | 2-Guanidinoethylmercaptosuccinic acid | | Synonyms: | GUANIDINOETHYLMERCAPTO-SUCCINIC ACID;GEMSA;(2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID 99+%;(2-Guanidinoethylthio)succinic acid, GEMSA;2-(2-Guanidinoethylthio)succinic acid;2-[(2-Guanidinoethyl)thio]succinic acid;2-Guanidinoethylthiosuccinic acid;2-[(2-carbaMiMidaMidoethyl)sulfanyl]succinicacid | | CAS: | 77482-44-1 | | MF: | C7H13N3O4S | | MW: | 235.26 | | EINECS: | | | Product Categories: | | | Mol File: | 77482-44-1.mol |  |
| | 2-Guanidinoethylmercaptosuccinic acid Chemical Properties |
| Melting point | ~180 °C (dec.) | | Boiling point | 412.877±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.598±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | White solid | | pka | 3.483±0.23(predicted) | | color | white | | Water Solubility | water: soluble | | InChI | 1S/C7H13N3O4S/c8-7(9)10-1-2-15-4(6(13)14)3-5(11)12/h4H,1-3H2,(H,11,12)(H,13,14)(H4,8,9,10) | | InChIKey | VKVCLXDFOQQABP-UHFFFAOYSA-N | | SMILES | S(C(CC(=O)O)C(=O)O)CCN=C(N)N |
| Safety Statements | 22-24/25 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-Guanidinoethylmercaptosuccinic acid Usage And Synthesis |
| Uses | GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1]. | | Biological Activity | ki: 8.8 nm2-guanidinoethylmercaptosuccinic acid is a carboxypeptidase e inhibitor.carboxypeptidase e, also known as enkephalin convertase, can remove c-terminal residues during the processing of propeptides, such as enkephalin and proinsulin. | | in vitro | 2-guanidinoethylmercaptosuccinic acid was identified as a biproduct analogs of lysine and arginine that showed potent inhibitory effect on enkephalin convertase with the ki value of 8.8 nm. in addition, 2-guanidinoethylmercaptosuccinic acid was found to be several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase b or n and the kinetic analyses indicated the pure competitive nature of the inhibition [1]. | | in vivo | previous study found that following the intrathecal administration of 2-guanidinoethylmercaptosuccinic acid at 12.5, 25 and 50 micrograms, an increase in the tail-flick latency was seen. in addition, 2-guanidinoethylmercaptosuccinic acid could potentiate the analgesic effects of the intrathecally applied met5-enkephalin-arg6-phe7 and met5-enkephalin-arg6-gly7-leu8. all these effects of 2-guanidinoethylmercaptosuccinic acid were significantly attenuated by the treatment of naloxone. moreover, the rats subjected to chronic pain showed a weaker analgesic response to the treatment of 2-guanidinoethylmercaptosuccinic acid. furthermore, 2-guanidinoethylmercaptosuccinic acid bound to enkephalin convertase in the spinal cord of these rats produced only a slight increase in kd [2]. | | references | 1. fricker ld, plummer th jr, snyder sh. enkephalin convertase: potent, selective, and irreversible inhibitors. biochem biophys res commun. 1983 mar 29;111(3):994-1000.2. m. bommer, k. nikolarakis, e. p. noble, et al. in vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (gemsa): possible physiological role of enkephalin convertase. brain research 492(1-2), 305-313 (1989). |
| | 2-Guanidinoethylmercaptosuccinic acid Preparation Products And Raw materials |
|