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| | (R)-2,2,2-Trifluoro-1-phenyl-ethylamine Basic information |
| Product Name: | (R)-2,2,2-Trifluoro-1-phenyl-ethylamine | | Synonyms: | (R)-2,2,2-TRIFLUORO-1-PHENYLETHANAMINE;(R)-(-)-alpha-(trifluoromethyl)benzylamine;(1R)-1-Phenyl-2,2,2-trifluoroethanamine;[(R)-α-(Trifluoromethyl)benzyl]amine;[R,(-)]-α-(Trifluoromethyl)benzylamine;Einecs 244-747-2;Benzenemethanamine, .alpha.-(trifluoromethyl)-, (.alpha.R)-;2,2,2-trifluoro-1-phenylethan-1-aMine | | CAS: | 22038-85-3 | | MF: | C8H8F3N | | MW: | 175.15 | | EINECS: | 244-747-2 | | Product Categories: | | | Mol File: | 22038-85-3.mol |  |
| | (R)-2,2,2-Trifluoro-1-phenyl-ethylamine Chemical Properties |
| Boiling point | 196.4±40.0 °C(Predicted) | | density | 1.224±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 6.15±0.10(Predicted) | | Appearance | White to off-white Solid |
| | (R)-2,2,2-Trifluoro-1-phenyl-ethylamine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of (R)-2,2,2-trifluoro-1-phenylethylamine from 1-phenyl-2,2,2-trifluoroethylamine:
1. Intermediate preparation: L-tartaric acid (36 g, 240.0 mmol) was added to a solution of 1-phenyl-2,2,2-trifluoroethylamine (40 g, 228.57 mmol) in isopropanol (400 mL).
2. Reaction: The reaction mixture was heated to reflux and maintained for 30 minutes.
3. Post-treatment: After completion of the reaction, the mixture was cooled to room temperature and the solid formed was collected by filtration.
4. Purification: The resulting solid was diluted with Na2CO3/H2O solution and subsequently extracted with dichloromethane (3 x 100 mL).
5. Drying and concentration: The organic phases were combined, dried over K2CO3 and subsequently concentrated under reduced pressure to afford the target product (1R)-2,2,2-trifluoro-1-phenylethylamine (12.5 g, 31% yield) as a white solid. | | References | [1] Patent: WO2011/119701, 2011, A1. Location in patent: Page/Page column 40 |
| | (R)-2,2,2-Trifluoro-1-phenyl-ethylamine Preparation Products And Raw materials |
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