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| | 2-(broMoMethyl)-6-Methoxypyridine Basic information |
| | 2-(broMoMethyl)-6-Methoxypyridine Chemical Properties |
| Boiling point | 229.3±25.0 °C(Predicted) | | density | 1.484±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 1.61±0.12(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 2-(broMoMethyl)-6-Methoxypyridine Usage And Synthesis |
| Synthesis | Under nitrogen protection, 1.07 g (6.01 mmol) of N-bromosuccinimide (NBS) and 49.3 mg (0.300 mmol) of azobisisobutyronitrile (AIBN) were dissolved in 8 mL of carbon tetrachloride (CCl4). Subsequently, the mixture was heated to reflux and 0.73 mL (6.00 mmol) of 2-methoxy-6-methylpyridine was slowly added. After keeping the reaction at reflux for 8 hours in an oil bath, the reaction mixture was cooled to room temperature. The crude product was concentrated under reduced pressure and purified by silica gel column chromatography [eluent: chloroform/hexane = 1:1 (v/v)] to afford 619 mg (66% yield) of the target compound 2-(bromomethyl)-6-methoxypyridine as a colorless liquid.1H NMR (400 MHz, CDCl3) δ 7.55 (dd, J = 8.2 Hz, J = 7.3 Hz, 1H ), 7.32 (d, J = 7.3 Hz, 1H), 6.99 (d, J = 8.2 Hz, 1H), 4.56 (s, 2H), 3.94 (s, 3H). | | References | [1] Bulletin of the Chemical Society of Japan, 2015, vol. 88, # 7, p. 963 - 965 |
| | 2-(broMoMethyl)-6-Methoxypyridine Preparation Products And Raw materials |
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