4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid

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4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid manufacturers
4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid Basic information
Product Name:4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
Synonyms:LIN28 inhibitor LI71 enantiomer;4-[(3aS,4R,9bR)-6-Ethoxy-3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-4-yl]benzoic acid;Compound T41114(SC);4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid
CAS:956189-58-5
MF:C21H21NO3
MW:335.4
EINECS:
Product Categories:
Mol File:Mol File
4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid Structure
4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid Chemical Properties
Boiling point 524.801±50.00 °C(Press: 760.00 Torr)(predicted)
density 1.211±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form Solid
pka4.027±0.10(predicted)
color White to yellow
Safety Information
HS Code 2933998090
MSDS Information
4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid Usage And Synthesis
UsesLIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM[1].
References[1] Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101. DOI:10.1016/j.celrep.2018.04.116
4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid Preparation Products And Raw materials
Tag:4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid(956189-58-5) Related Product Information
GG-43 (3aR,4S,9bS)-4-phenyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic LIN28 inhibitor LI71 NA 4-[(3aR,4S,9bS)-6-Ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoic acid 3H-Cyclopenta[c]quinoline-8-carboxylic acid, 3a,4,5,9b-tetrahydro-4-phenyl-, (3aR,9bS)-