Cefazolin-13C2-15N manufacturers
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| | Cefazolin-13C2-15N Basic information |
| Product Name: | Cefazolin-13C2-15N | | Synonyms: | Cefazolin-13C2-15N;(6R,7R)-7-(2-(1H-tetrazol-1-yl-1-15N)acetamido-13C2-13C2)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid | | CAS: | 2101505-58-0 | | MF: | C14H14N8O4S3 | | MW: | 457.53416 | | EINECS: | | | Product Categories: | | | Mol File: | 2101505-58-0.mol |  |
| | Cefazolin-13C2-15N Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble | | form | A solid |
| | Cefazolin-13C2-15N Usage And Synthesis |
| Description | Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections. | | Uses | Cefazolin-13C2,15N (Cephazolin-13C2,15N) is 13C and 15N labeled Cefazolin. Cefazolin (Cephazolin) is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6. DOI:10.7326/0003-4819-89-5-650
[3] Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235. DOI:10.1186/s12974-018-1274-6
[4] Barbara yyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10(1):2886. DOI:10.1038/s41598-020-59798-3 |
| | Cefazolin-13C2-15N Preparation Products And Raw materials |
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