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Folinic acid calcium salt pentahydrate manufacturers
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| | Folinic acid calcium salt pentahydrate Basic information |
| Product Name: | Folinic acid calcium salt pentahydrate | | Synonyms: | 5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE;5-HCO-H4PTEGLU CALCIUM SALT PENTAHYDRATE;LEUCOVORIN PENTAHYDRATE;CITROVORUM FACTOR CALCIUM SALT PENTAHYDRATE;N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE;FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP | | CAS: | 41927-89-3 | | MF: | C20H31CaN7O12 | | MW: | 601.58 | | EINECS: | | | Product Categories: | | | Mol File: | 41927-89-3.mol |  |
| | Folinic acid calcium salt pentahydrate Chemical Properties |
| Melting point | 240-250 °C | | storage temp. | 0-6°C | | solubility | Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated) | | form | Solid | | color | Off-White to Pale Yellow | | Stability: | Hygroscopic |
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ACROS
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| | Folinic acid calcium salt pentahydrate Usage And Synthesis |
| Uses | Anti-anemic (folate deficiency); antidote (to folic acid
antagonists). | | Brand name | Wellcovorin (GlaxoSmithKline). | | Clinical Use | Folinic acid rescue
Enhancement of 5-fluorouracil cytotoxicity in
advanced colorectal cancer
Folate deficiency | | Drug interactions | Potentially hazardous interactions with other drugs
Should not be administered simultaneously with a
folic acid antagonist as this may nullify the effect of
the antagonist.
Cytotoxics: avoid with panitumumab and raltitrexed. | | Metabolism | Folinic acid is a racemate where the L-form (L-5-
formyl-tetrahydrofolate, L-5-formyl-THF), is the active
enantiomer. The major metabolic product of folinic acid
is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which
is predominantly produced in the liver and intestinal
mucosa.
80-90% with the urine (5- and 10-formyltetrahydrofolates
inactive metabolites), 5-8% with the
faeces. |
| | Folinic acid calcium salt pentahydrate Preparation Products And Raw materials |
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