AP-761 manufacturers
- BI-671800
-
- $44.00
-
2026-07-15
- CAS:1093108-50-9
- Purity: 99.19%
- Supply Ability: 10g
- BI-671800
-
- $44.00
-
2026-07-15
- CAS:1093108-50-9
- Purity: 99.19%
- Supply Ability: 10g
- AP-761
-
- $2.00
-
2020-01-09
- CAS:1093108-50-9
- Min. Order: 1g
- Purity: 98%min
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| Product Name: | AP-761 | | Synonyms: | AP-761;5-Pyrimidineacetic acid, 4,6-bis(dimethylamino)-2-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]-;BI671800;BI671800;AP-761;AP761;AP 761;BI 671800
(BI671800);AP-761 / BI671800;BI-67180;BI-671800,BI671800,Inhibitor,BI 671800,Prostaglandin Receptor,inhibit | | CAS: | 1093108-50-9 | | MF: | C25H26F3N5O3 | | MW: | 501.5 | | EINECS: | | | Product Categories: | AP-761 | | Mol File: | 1093108-50-9.mol |  |
| | AP-761 Chemical Properties |
| Boiling point | 611.4±55.0 °C(Predicted) | | density | 1.351±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 3.20±0.10(Predicted) | | color | White to off-white |
| | AP-761 Usage And Synthesis |
| Uses | BI-671800 is a selective and potent CRTH2 antagonist. | | in vivo | BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1].
BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3]. | Animal Model: | 6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally)[1].
| | Dosage: | 10-0.1 mg/kg | | Administration: | Oral gavage for 4 weeks | | Result: | Shows significant inhibition of AHR in mice. |
| | IC 50 | hCRTH2: 4.5 nM (IC50); mCRTH2: 3.7 μM (IC50) |
| | AP-761 Preparation Products And Raw materials |
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