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Cool Pharm, Ltd |
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021-60455363 18019463053 |
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BePharm Ltd |
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| | tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Basic information |
| | tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Chemical Properties |
| Boiling point | 469.3±40.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 0.41±0.20(Predicted) |
| | tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Usage And Synthesis |
| Synthesis | 3-Oxo-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (0.200 g, 0.999 mmol) and 1-bromo-4-fluorobenzene (0.091 mL, 0.832 mmol) were added with copper(I) iodide (0.008 g, 0.042 mmol), potassium carbonate (0.230 g, 1.665 mmol) and N,N'-dimethyl- 1,2-ethylenediamine (0.009 mL, 0.083 mmol) in toluene (5 mL). The mixture was heated to reflux overnight under nitrogen protection. Upon completion of the reaction, the reaction mixture was filtered through a pad of silica gel. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford 4-(4-fluorophenyl)-3-oxo-1-piperazinecarboxylic acid 1,1-dimethylethyl ester (0.180 g, 73% yield) as a white solid. | | References | [1] Patent: WO2011/41713, 2011, A2. Location in patent: Page/Page column 152
[2] Patent: WO2014/9872, 2014, A1. Location in patent: Page/Page column 63; 64
[3] Patent: US2015/152118, 2015, A1. Location in patent: Paragraph 0382 - 0385 |
| | tert-Butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate Preparation Products And Raw materials |
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