[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper

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[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper manufacturers

  • CuATSM
  • CuATSM pictures
  • 2026-07-15
  • CAS:68341-09-3
  • Purity: 97.01%
  • Supply Ability: 10g
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Basic information
Product Name:[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper
Synonyms:[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper;Cu-ASTM;CuII(atsm);Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II);CUAM;Cu-ASTM >=98% (HPLC);Cu-ATSM?68341-09-3?Cu-ATSM;Cu-ATSM
CAS:68341-09-3
MF:C8H14CuN6S2
MW:321.92
EINECS:
Product Categories:
Mol File:68341-09-3.mol
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Structure
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Chemical Properties
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
color brown to dark red-brown
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Usage And Synthesis
UsesCu-ATSM is preclinically used as a potential therapy for ALS (amyotrophic lateral sclerosis). A potential anti-Alzheimer''s agent.
Biochem/physiol ActionsCu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that specifically inhibits the action of peroxynitrite on Cu,Zn superoxide dismutase (SOD1) and subsequent nitration of cellular proteins. CuII(ATSM) significantly delayed onset of disease (paralysis and prolonged lifespan) in amyotrophic lateral sclerosis (ALS) mice model. Also, Cu-ATSM was reported to lower lipid peroxidation in a model of ischemicreperfusion injury. Cu-ATSM subsequently was shown to inhibit ferroptosis with a potency similar to Liproxstatin-1.
in vivo

CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model[2].

Animal Model:Mouse transient middle cerebral artery occlusion (tMCAO) model[2]
Dosage:1.5 mg/kg
Administration:iv, single dose
Result:Reduced the expression of oxidative stress markers such as 4-HNE, 8-OHdG, and nitrotyrosine.
[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper Preparation Products And Raw materials
Tag:[[2,2′-(1,2-Dimethyl-1,2-ethanediylidene)bis[N-methylhydrazinecarbothioamidato]]] copper(68341-09-3) Related Product Information
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