BD-1047盐酸盐
| 中文名称 | BD-1047盐酸盐 |
|---|---|
| 中文同义词 | N-[2-(3,4-二氯苯基)乙基]-N,N',N'-三甲基-1,2-乙二胺二氢溴酸盐;化合物BD1047.2HBR;BD-1047盐酸盐;N1-(3,4-二氯苯乙基)-N1,N2,N2-三甲基乙-1,2-二胺二溴化氢盐;BD-1047二氢溴酸盐;BD 1047 DIHYDROBROMIDE,SIGMA1 RECEPTOR拮抗剂;化合物BD1047.2HBR,10 MM DMSO 溶液;BD-1047 dihydrobromide试剂 |
| 英文名称 | BD 1047 dihydrobromide |
| 英文同义词 | BD 1047 HBr;BD-1047;BD 1047;169592;BD1047.2HBr(1K/g);n-[2-(3,4-dichlorophenyl)ethyl]-n,n',n'-trimethylethane-1,2-diamine dihydrobromide;BD 1047 (hydrobromide);1,2-ethanediamine, N-[2-(3,4-dichlorophenyl)ethyl]-N,N',N'-trimethyl-, dihydrobromide;N1-(3,4-dichlorophenethyl)-N1,N2,N2-trimethylethane-1,2-diamine dihydrobromide |
| CAS号 | 138356-21-5 |
| 分子式 | C13H22Br2Cl2N2 |
| 分子量 | 437.04118 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;Inhibitors |
| Mol文件 | 138356-21-5.mol |
| 结构式 |  |
BD-1047盐酸盐 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度>5mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色 |
| 水溶解性 | H2O: >5mg/mL |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或蒸馏水中的溶液可在 -20°C 下保存长达 3 个月。 |
| InChI | 1S/C13H20Cl2N2.2BrH/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11;;/h4-5,10H,6-9H2,1-3H3;2*1H |
| InChIKey | WOALTFHGLDVJHK-UHFFFAOYSA-N |
| SMILES | Br.Br.CN(C)CCN(C)CCc1ccc(Cl)c(Cl)c1 |
| Target | Value |
|
σ1 receptor
() |
BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.
BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.
| Animal Model: | Male Albino Swiss mice (50 days old, 25–28 g) |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased the APO-induced climbing at the dose of 10 mg/kg in mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-16996AR | BD-1047盐酸盐 BD-1047 dihydrobromide (Standard) | 138356-21-5 | 5 mg | 1400元 |
| 2026/09/15 | HY-16996AR | BD-1047盐酸盐 BD-1047 dihydrobromide (Standard) | 138356-21-5 | 10 mg | 2240元 |