N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

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N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide manufacturers

  • Lin281632
  • Lin281632 pictures
  • $30.00
  • 2026-04-21
  • CAS:108825-65-6
  • Purity: 99.84%
  • Supply Ability: 10g
N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide Basic information
Product Name:N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
Synonyms:Lin28 1632;Lin28-IN-1632;Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-;Lin 28 163;Lin28-let-7 antagonist 1;Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632;C1632;Lin281632, 10 mM in DMSO
CAS:108825-65-6
MF:C15H15N5O
MW:281.31
EINECS:
Product Categories:
Mol File:108825-65-6.mol
N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide Structure
N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide Chemical Properties
Melting point 200 °C
density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
form A crystalline solid
pka0.57±0.30(Predicted)
color Off-white to light yellow
InChI1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
InChIKeyWPAQLESUVYGUJZ-UHFFFAOYSA-N
SMILES[n]21nc(ccc2nnc1C)c3cc(ccc3)N(C)C(=O)C
Safety Information
Hazard Codes Xi
WGK Germany WGK 3
Hazard Note Irritant
HS Code 2933998090
Storage Class11 - Combustible Solids
MSDS Information
N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide Usage And Synthesis
UsesLin28 1632 is a small molecule inhibitor of Lin28.
Biological ActivityCompound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNA, but not RNU44 snoRNA (60 μM for 48h), inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs, 20 μM for 48h), as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM).
storageStore at +4°C
N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide Preparation Products And Raw materials
Tag:N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide(108825-65-6) Related Product Information
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