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| | ARP 101 Basic information |
| Product Name: | ARP 101 | | Synonyms: | Butanamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-3-methyl-, (2R)-;(R)-N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-sulfonamido)-3-methylbutanamide , ARP101;(R)-N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-sulfonamido)-3-methylbutanamide | | CAS: | 849773-63-3 | | MF: | C20H26N2O5S | | MW: | 406.5 | | EINECS: | | | Product Categories: | | | Mol File: | 849773-63-3.mol |  |
| | ARP 101 Chemical Properties |
| storage temp. | Desiccate at 4°C | | solubility | <40.65mg/ml in DMSO; <10.16mg/ml in ethanol | | form | solid | | color | White |
| | ARP 101 Usage And Synthesis |
| Uses | ARP101 is a potent and selective inhibitor matrix metalloproteinase-2 (MMP-2). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 is effective in inducing the formation of autophagosome and conversion of LC3I into LC3II[1]. | | Definition | ChEBI: N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide is a hydroxamic acid that is N-hydroxy-D-valinamide in which the alpha-amino group has been substituted by isopropoxy and [biphenyl]-4-ylsulfonyl groups. A selective matrix metalloproteinase-2 (MMP-2) inhibitor, it is one of the most potent inducers of autophagy. Its physiological roles include angiogenesis, cancer metastasis, embryogenesis, tissue remodeling in development, and wound healing. It has a role as an EC 3.4.24.24 (gelatinase A) inhibitor, an autophagy inducer, an antineoplastic agent and a melanin synthesis inhibitor. It is a hydroxamic acid and a D-valine derivative. | | storage | Desiccate at +4°C | | References | [1] Jo YK, et al. ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. Biochem Biophys Res Commun. 2011;404(4):1039-1043. DOI:10.1016/j.bbrc.2010.12.106 |
| | ARP 101 Preparation Products And Raw materials |
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