2-(4-Bromophenyl)-2-oxoacetic acid manufacturers
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| | 2-(4-Bromophenyl)-2-oxoacetic acid Basic information |
| | 2-(4-Bromophenyl)-2-oxoacetic acid Chemical Properties |
| Melting point | 89 °C | | Boiling point | 152-155 °C(Press: 3 Torr) | | density | 1.738±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.03±0.54(Predicted) | | Appearance | White to off-white Solid |
| | 2-(4-Bromophenyl)-2-oxoacetic acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-(4-bromophenyl)-2-oxoacetic acid from the compound (CAS: 58881-56-4) was as follows: selenium dioxide (1.5 mmol) was dissolved in 1,4-dioxane (10.0 mL) and the solution was transferred to a 50 mL round bottom flask. Subsequently, dibenzoyl sulfide derivative 1 (0.5 mmol) was added to the solution and the reaction mixture was heated to reflux for 2 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was filtered to remove insoluble impurities and the solvent was subsequently evaporated under reduced pressure. The crude product was purified by column chromatography using a solvent mixture of petroleum ether and ethyl acetate (90:10, v/v) as eluent to give the final target product 2-(4-bromophenyl)-2-oxoacetic acid. | | References | [1] Journal of Sulfur Chemistry, 2014, vol. 35, # 1, p. 24 - 30 |
| | 2-(4-Bromophenyl)-2-oxoacetic acid Preparation Products And Raw materials |
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