THS-044 manufacturers
- THS-044
-
- $44.00
-
2026-06-08
- CAS:62054-67-5
- Purity: 99.89%
- Supply Ability: 10g
- THS-044
-
- $44.00
-
2026-06-08
- CAS:62054-67-5
- Purity: 99.89%
- Supply Ability: 10g
- THS-044
-
-
2026-02-02
- CAS:62054-67-5
- Purity: 98%HPLC
- Supply Ability: 200tons
|
| | THS-044 Basic information |
| Product Name: | THS-044 | | Synonyms: | THS044;THS 044;THS-044;4-Morpholinamine, N-[2-nitro-4-(trifluoromethyl)phenyl]-;N-(2-Nitro-4-(trifluoromethyl)phenyl)morpholin-4-amine | | CAS: | 62054-67-5 | | MF: | C11H12F3N3O3 | | MW: | 291.23 | | EINECS: | 610-261-8 | | Product Categories: | | | Mol File: | 62054-67-5.mol |  |
| | THS-044 Chemical Properties |
| Melting point | 106-108 °C | | Boiling point | 347.1±52.0 °C(Predicted) | | density | 1.464±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | -0.19±0.50(Predicted) | | color | Yellow to orange |
| | THS-044 Usage And Synthesis |
| Uses | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
Target: HIF2α
Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein. | | References | [1] Motto I, et al. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011 Nov 28;51(11):2868-2881. DOI:10.1021/ci2001617
[2] Scheuermann TH, et al. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-455. DOI:10.1073/pnas.0808092106 |
| | THS-044 Preparation Products And Raw materials |
|