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| | Azido-PEG1-PFP ester Basic information |
| Product Name: | Azido-PEG1-PFP ester | | Synonyms: | Azido-PEG1-PFP ester;(2,3,4,5,6-pentafluorophenyl) 3-(2-azidoethoxy)propanoate;perfluorophenyl 3-(2-azidoethoxy)propanoate;Pentafluorophenyl 3-(2-azidoethoxy)propanoate;N3-PEG1-CH2CH2COOPFP;Perfluorophenyl 3-(2-azidoethoxy)propanoate , Azido-PEG1-PFP ester;2,3,4,5,6-pentafluorophenyl-3-(2-azaethoxy)propanoic acidester | | CAS: | 1807505-32-3 | | MF: | C11H8F5N3O3 | | MW: | 325.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1807505-32-3.mol |  |
| | Azido-PEG1-PFP ester Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | Azido-PEG1-PFP ester Usage And Synthesis |
| Description | Azido-PEG1-PFP ester is a click chemistry PEG linker containing azide and PFP ester moities. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester. | | Uses | Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG1-PFP ester Preparation Products And Raw materials |
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