| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 29-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester
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2026-07-24
- CAS:1334170-03-4
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
- Fmoc-PEG8-NHS ester
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2026-07-10
- CAS:1334170-03-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kgs
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| | Fmoc-PEG8-NHS ester Basic information |
| Product Name: | Fmoc-PEG8-NHS ester | | Synonyms: | FmocNH-PEG8-CH2CH2COONHS;Fmoc-PEG8-NHS ester;Fmoc-NH-PEG8-NHS;Fmoc-N-amido-PEG8-NHS ester;FmocNH-PEG8-NHS?ester;Fmoc-N-amido-dPEG (R)8-NHS ester;5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid, 29-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester;alpha-(Fmoc-amino)-omega-(succinimidyl propionate) octa(ethylene glycol) | | CAS: | 1334170-03-4 | | MF: | C38H52N2O14 | | MW: | 760.82 | | EINECS: | | | Product Categories: | | | Mol File: | 1334170-03-4.mol |  |
| | Fmoc-PEG8-NHS ester Chemical Properties |
| density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.60±0.46(Predicted) | | form | Liquid | | color | Colorless to light yellow | | InChIKey | AMSAHSNOOQLQOU-UHFFFAOYSA-N | | SMILES | O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Fmoc-PEG8-NHS ester Usage And Synthesis |
| Description | Fmoc-PEG8-NHS ester is a PEG linker containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | reaction suitability | reaction type: Pegylations
reagent type: cross-linking reagent | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Fmoc-PEG8-NHS ester Preparation Products And Raw materials |
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