|
|
| | Fmoc-PEG12-NHS ester Basic information | | Purity |
| Product Name: | Fmoc-PEG12-NHS ester | | Synonyms: | Fmoc-PEG12-NHS ester;FmocNH-PEG12-NHS?ester;FmocNH-PEG12-CH2CH2COONHS;5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 41-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG12-NHS;Inhibitor,Fmoc-PEG-12-NHS ester,FmocPEG12NHS ester,PROTAC Linkers,Fmoc PEG12 NHS ester,inhibit;FmocNH-PEG12-CH2CH2COONHS/5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 41-(2,5-dioxo-1-pyrrolidinyl) 1-(9H-fluoren-9-ylmethyl) ester;2,5-Dioxopyrrolidin-1-yl 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxa-4-azatritetracontan-43-oate | | CAS: | 2227246-92-4 | | MF: | C46H68N2O18 | | MW: | 937.03 | | EINECS: | | | Product Categories: | | | Mol File: | 2227246-92-4.mol |  |
| | Fmoc-PEG12-NHS ester Chemical Properties |
| storage temp. | Storage temp. -20°C | | solubility | Soluble in DCM | | form | Viscous Liquid | | color | Colorless to light yellow | | Stability: | >=2 years | | InChIKey | HQKUPHFWWTZASE-UHFFFAOYSA-N | | SMILES | C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |
| | Fmoc-PEG12-NHS ester Usage And Synthesis |
| Purity | >98% | | Description | Fmoc-PEG12-NHS ester is a PEG linker containing an Fmoc-protected amine and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | | Uses | Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Uses | Fmoc-PEG12-NHS ester (CAS 2227246-92-4) is a high-purity heterobifunctional PROTAC linker. Its synonyms include: FmocNH-PEG12-NHS ester, Fmoc-N-amido-PEG12-NHS ester, FmocNH-PEG12-CH₂CH₂COONHS, Fmoc-NH-PEG12-CH₂CH₂COONHS ester, and 2,5-Dioxopyrrolidin-1 -yl 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxa-4-azatritetracontan-43-oate, amongst others. This compound contains functional groups comprising Fmoc-protected amines and NHS esters, whilst the hydrophilic polyethylene glycol (PEG) spacer improves its water solubility. It is widely used in site-specific biocoupling, the synthesis of PROTACs, and the modification of proteins or oligonucleotides. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Fmoc-PEG12-NHS ester Preparation Products And Raw materials |
|