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| Product Name: | 7BIO | | Synonyms: | 7BIO;7BIO - CAS 916440-85-2 - Calbiochem;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7BIO, 10 mM in DMSO | | CAS: | 916440-85-2 | | MF: | C16H10BrN3O2 | | MW: | 356.17 | | EINECS: | | | Product Categories: | | | Mol File: | 916440-85-2.mol |  |
| Melting point | 293 °C | | Boiling point | 565.541±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.805±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | +2C to +8C | | solubility | Soluble in ethanol;DMSO | | form | Deep black-red solid | | pka | 8.499±0.20(predicted) | | color | Dark red |
| Description | 7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC50 = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 μM, respectively. | | Uses | 7BIO is a caspase independent nonapoptotic cell death inducer. | | in vivo | 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) significantly attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice[1].
7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) decreases Aβ oligomer-induced increase of TNF-α and IL-6 production in the brain and the expression of synapsin-1 and PSD-95 in the hippocampal region of mice[1].
7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) attenuates Aβ oligomer-induced increase expression of pTau, activation of microglia and astrogliosis in the brain of mice[1].
7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) prevents decreased expression of pSer9-GSK3β and has no significant effects on the Tau protein level[1]. | Animal Model: | 8 weeks mice (30 g)[1] | | Dosage: | 2.3, 7.0, and 23.3 μg/kg | | Administration: | bilateral ventricle injection | | Result: | Attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice. |
| | IC 50 | CDK5; GSK3β | | storage | +4°C | | references | [1] ribas j, bettayeb k, ferandin y, et al. 7-bromoindirubin-3′-oxime induces caspase-independent cell death[j]. oncogene, 2006, 25(47): 6304-6318.
[2] myrianthopoulos v, kritsanida m, gaboriaud-kolar n, et al. novel inverse binding mode of indirubin derivatives yields improved selectivity for dyrk kinases[j]. acs medicinal chemistry letters, 2012, 4(1): 22-26.
[3] myrianthopoulos v, magiatis p, ferandin y, et al. an integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases b and c by a series of 7-substituted indirubins[j]. journal of medicinal chemistry, 2007, 50(17): 4027-4037. |
| | 7BIO Preparation Products And Raw materials |
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