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CP 376395 hydrochloride manufacturers
- CP-376395 HCl
-
-
2025-12-22
- CAS:1013933-37-3
- Purity:
- Supply Ability: 10g
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| | CP 376395 hydrochloride Basic information |
| Product Name: | CP 376395 hydrochloride | | Synonyms: | CP-376395 HCl;CP 376395 hydrochloride
(CP376395;CP-376395 hydrochloride >=98% (HPLC);UNII-5113G7FP34;CP 376395 HCl,CP376395 HCl;4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-, hydrochloride (1:1) | | CAS: | 1013933-37-3 | | MF: | C21H30N2O.ClH | | MW: | 362.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1013933-37-3.mol |  |
| | CP 376395 hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 50 mM in water and to 100 mM in DMSO | | form | Powder | | color | white to beige | | InChI | 1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H | | InChIKey | UDIOZDHQQNYISB-UHFFFAOYSA-N | | SMILES | CC1=C(NC(CC)CC)C=C(C)N=C1OC2=C(C)C=C(C)C=C2C.[H]Cl |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | CP 376395 hydrochloride Usage And Synthesis |
| Description | Potent and selective CRF1receptor antagonist (Kivalues are 12 and >10000 nM for CRF1and CRF2receptors respectively). Attenuates CRF-induced activation of the HPA axisin vivofollowing i.v. administration. Orally active. | | Uses | CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2]. | | in vivo | CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference[2]. | Animal Model: | Male B6 mice (n=8-9 per group)[2] | | Dosage: | 0.0, 10.0, or 20.0 mg/kg | | Administration: | Intraperitoneally | | Result: | Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session. |
| | IC 50 | CRFR1; CRFR2 | | storage | Desiccate at RT | | References | [1] Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. DOI:10.1021/jm070579c
[2] Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70. DOI:10.1111/acer.12076 |
| | CP 376395 hydrochloride Preparation Products And Raw materials |
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