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| Product Name: | HUMAN MDC (CCL22) | | Synonyms: | ANTI-ADAM11 (N-TERM) antibody produced in rabbit;CHEMOKINE STCP-1;HUMAN MDC;HUMAN CCL22;HUMAN MDC (CCL22);HUMAN MDC (CCL22) CHEMICALLY SYNTHESIZED CHEMOKINE;HUMAN MACROPHAGE DERIVED CHEMOATTRACTANT;HUMAN MACROPHAGE-DERIVED CHEMOKINE | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUMAN MDC (CCL22) Structure]() |
| | HUMAN MDC (CCL22) Chemical Properties |
| storage temp. | −20°C | | form | lyophilized powder |
| | HUMAN MDC (CCL22) Usage And Synthesis |
| Description | MDC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 8.1 kDa.
The MDC is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16.
MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4.
CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph node CCL22 is expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+).
Furthermore, CCL22 is expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. In addition, MDC has a role in hindering progression of lung cancer. Moreover, significantly higher CCL22 expression is linked to gastric cancer. |
| | HUMAN MDC (CCL22) Preparation Products And Raw materials |
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