| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PKCε Inhibitor Peptide manufacturers
- Epsilon-V1-2
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- $147.00
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2026-07-15
- CAS:182683-50-7
- Purity: 97.09%
- Supply Ability: 10g
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| | PKCε Inhibitor Peptide Basic information |
| Product Name: | PKCε Inhibitor Peptide | | Synonyms: | KNTBAGOTDJPUJV-XMTFRXHISA-N;L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;epsilonV1-2;L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-;ε-V1-2 | | CAS: | 182683-50-7 | | MF: | C37H65N9O13 | | MW: | 843.96 | | EINECS: | | | Product Categories: | | | Mol File: | 182683-50-7.mol |  |
| | PKCε Inhibitor Peptide Chemical Properties |
| Boiling point | 1280.1±65.0 °C(Predicted) | | density | 1.288±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml | | form | A crystalline solid | | pka | 3.28±0.10(Predicted) | | color | White to off-white |
| | PKCε Inhibitor Peptide Usage And Synthesis |
| Uses | L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine selectively and reversibly inhibits the translocation of PKC to intracellular membranes, blocking activation. It is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase. | | in vivo | Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels[3]. | Animal Model: | C57BL/6J mice transplanted the hearts of FVB mice[3] | | Dosage: | 20 mg/kg/day | | Administration: | 0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks | | Result: | Significantly improved the beating score throughout the treatment.
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| | IC 50 | PKCε |
| | PKCε Inhibitor Peptide Preparation Products And Raw materials |
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