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| | PKCζ Pseudosubstrate Inhibitor Basic information |
| Product Name: | PKCζ Pseudosubstrate Inhibitor | | Synonyms: | PKCζ Pseudosubstrate Inhibitor;PKC.zeta. Pseudosubstrate Inhibitor;Pseudosubstrate Inhibitor;PKCζ Pseudosubstrate Inhibitor (Protein Kinase Cζ Pseudosubstrate Inhibitor);L-Leucine, L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl- | | CAS: | 799764-07-1 | | MF: | C76H128N30O16 | | MW: | 1718.02 | | EINECS: | | | Product Categories: | | | Mol File: | 799764-07-1.mol |  |
| | PKCζ Pseudosubstrate Inhibitor Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 20 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | Water Solubility | glacial acetic acid: 2mg/mL
water: 2mg/mL | | Sequence | Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu |
| | PKCζ Pseudosubstrate Inhibitor Usage And Synthesis |
| Description | The atypical protein kinase C isoform, PKCζ, is critical for mediating mitogenic signal transduction, cell survival, and some of the physiological actions of insulin.1 PKCζ pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform.2 It selectively, reversibly, and substrate-competitively inhibits PKCζ activity and, thus, is used to delineate the signaling functions of PKCζ.3,4,5 | | Uses | PKCζ/ι pseudosubstrate inhibitor has broad-spectrum effects on the PKC enzyme family and can induce memory impairment[1]. | | References | 1. Toker, A. Signaling through protein kinase C Front. Biosci. 3,d1134-d1147(1998).
2. Eichholtz, T., de Bont, D.B.A., de Widt, J., et al. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor J. Biol. Chem. 268(3),1982-1986(1993).
3. Lee, A.W. The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages PLoS One 6(10),e25580(2011).
4. Dang, P.M.C., Fontayne, A., Hakim, J., et al. Protein kinase C ζ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst J. Immunol. 166,1206-1213(2001).
5. Standaert, M.L., Galloway, L., Karnam, P., et al. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport J. Biol. Chem. 272(48),30075-30082(1997). |
| | PKCζ Pseudosubstrate Inhibitor Preparation Products And Raw materials |
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