ONC212

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:ONC212
CAS:1807861-48-8
Purity:>=95% Package:1mg;44USD|5mg;98USD|10mg;162USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Products Intro: Product Name:ONC212
CAS:1807861-48-8
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Products Intro: Product Name:ONC212
CAS:1807861-48-8
Purity:99% Package:1gram;USD
Company Name: HANGZHOU LEAP CHEM CO., LTD.
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Products Intro: Product Name:ONC212
CAS:1807861-48-8
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:ONC212
CAS:1807861-48-8
Package:1 mL * 10mM (in DMSO)；10 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

ONC212 manufacturers

  • ONC212
  • ONC212 pictures
  • $44.00
  • 2026-05-11
  • CAS:1807861-48-8
  • Purity: 99.98%
  • Supply Ability: 10g
  • ONC212
  • ONC212 pictures
  • 2025-12-25
  • CAS:1807861-48-8
  • Min. Order: 1gram
  • Purity: 99%
  • Supply Ability: 10kg
ONC212 Basic information
Product Name:ONC212
Synonyms:ONC212;ONC 212;ONC-212;ONC212;1807861-48-8;ONC 212;ONC-212;Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-;7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one;DUN61488;ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis;ONC212, 10 mM in DMSO
CAS:1807861-48-8
MF:C24H23F3N4O
MW:440.46
EINECS:
Product Categories:APIs
Mol File:1807861-48-8.mol
ONC212 Structure
ONC212 Chemical Properties
Boiling point 549.9±60.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:1.0(Max Conc. mg/mL);2.27(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);57.89(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.57(Max Conc. mM)
form A crystalline solid
pka6.22±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
ONC212 Usage And Synthesis
UsesONC212, is an analogue of ONC201 (H291055), that is shown to a promising anti-cancer drug and also a selective agonist of GPR132.
in vivo

Biweekly oral administration of 50 mg/kg ONC212 markedly inhibits Acute myeloid leukemia (AML) expansion and prolongs overall survival (p=0.0003). Median survival increases from 43 d in controls to 49 d in the ONC212-treated group (+14%)[1].
ONC212 treatment exhibits significantly greater growth inhibition in comparison to ONC201. A dose of 50 mg/kg of ONC212 administered three-times a week is sufficient to lead to significant growth inhibition of tumors compare to the control group for these two models. Results demonstrate that ONC212 treated tumors show reduced proliferation in the HPAF-II model[2].
In vivo toxicity assessment experiments show that ONC212 is well tolerated up to 250 mg/kg. 300 mg/kg of ONC212 causes splenic damage and elevates liver enzymes. ONC212 has a slightly shorter half-life than ONC201, with a clearance from the blood at 12 hours, T1/2 of 4.3 hours, and Cmax of 1.4 μg/mL[3].

ONC212 Preparation Products And Raw materials
Tag:ONC212(1807861-48-8) Related Product Information
ONC206 ONC201 Dihydrochloride ONC212 7-benzyl-10-(2-Methylbenzyl)-2,6,7,8,9,10-hexahydroiMidazo[1,2-a]pyrido[4,3-d]pyriMidin-5(3H)-one