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| | 2-Methyl-3-biphenylmethanol Basic information |
| | 2-Methyl-3-biphenylmethanol Chemical Properties |
| Melting point | 73-76 °C(lit.) | | Boiling point | 330.9±11.0 °C(Predicted) | | density | 1.072±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.28±0.10(Predicted) | | form | Solid | | color | White to Off-White | | InChI | InChI=1S/C14H14O/c1-11-13(10-15)8-5-9-14(11)12-6-3-2-4-7-12/h2-9,15H,10H2,1H3 | | InChIKey | BGTLHJPGBIVQLJ-UHFFFAOYSA-N | | SMILES | C1(C2=CC=CC=C2)=CC=CC(CO)=C1C | | CAS DataBase Reference | 76350-90-8(CAS DataBase Reference) | | EPA Substance Registry System | [1,1'-Biphenyl]-3-methanol, 2-methyl- (76350-90-8) |
| WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2906290090 |
| | 2-Methyl-3-biphenylmethanol Usage And Synthesis |
| Description | 2-Methyl-3-biphenylmethanol is a pharmaceutical intermediate and organic chemical synthesis reagent, which can be used in the preparation of drugs such as Bifenthrin and PD-L1 inhibitors, and also in the synthesis of other organic compounds such as 2-methyl-3-phenylphenethylboronic acid pinacol ester, biphenyl-1,2,3-triazole couplings and biphenyl alcohols. | | Chemical Properties | white to light yellow crystal powde | | Uses | Bifenthrin intermediate. | | Application | 2-Methyl-3-biphenylmethanol is mainly used in the production of agricultural chemicals bifenthrin and the synthesis material of other pharmaceutical prods.
| | Hazard |
2-Methyl-3-biphenylmethanol causes skin irritation and serious eye irritation. It may cause respiratory irritation.
| | Synthesis |
Carrying out a Suzuki coupling reaction between 3-bromo-2-methylbenzoic acid and phenyl substituted boric acid or phenyl substituted borate to obtain 3-phenyl-2-methylbenzoic acid, and then carrying out a reduction reaction to obtain 2-Methyl-3-biphenylmethanol, wherein the Suzuki coupling reaction is carried out at 10-150°C for 1-12 hours under the action of an alkali. 3-phenyl-2-methylbenzoic acid can be directly reduced with a reducing agent such as borane and lithium aluminium hydride to obtain 2-Methyl-3-biphenylmethanol.
| | References | [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5857 - 5867
[2] Patent: WO2018/200571, 2018, A1. Location in patent: Page/Page column 44-45
[3] Patent: WO2015/34820, 2015, A1. Location in patent: Page/Page column 42
[4] Patent: US2015/291549, 2015, A1. Location in patent: Paragraph 0210; 0211
[5] Patent: WO2017/118762, 2017, A1. Location in patent: Page/Page column 39; 40 |
| | 2-Methyl-3-biphenylmethanol Preparation Products And Raw materials |
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