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BOC Sciences |
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1-631-485-4226; 16314854226 |
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MRS 1220 manufacturers
- MRS1220
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- $45.00
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2026-07-15
- CAS:183721-15-5
- Purity: 98.43%
- Supply Ability: 10g
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| | MRS 1220 Basic information |
| Product Name: | MRS 1220 | | Synonyms: | 9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-chloro-2-(2-furanyl)-5-((phenylacetyl)amino)-[1,2,4]triazolo[1,5-c]quinazoline;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA;Benzeneacetamide, N-[9-chloro-2-(2-furanyl)[1,2,4]triazolo[1,5-c]quinazolin-5-yl]- | | CAS: | 183721-15-5 | | MF: | C21H14ClN5O2 | | MW: | 403.82 | | EINECS: | | | Product Categories: | | | Mol File: | 183721-15-5.mol |  |
| | MRS 1220 Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO: 2 mg/mL | | form | solid | | pka | 8.17±0.46(Predicted) | | color | white | | InChI | 1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28) | | InChIKey | TWWFAXQOKNBUCR-UHFFFAOYSA-N | | SMILES | Clc1ccc2nc(NC(=O)Cc3ccccc3)n4nc(nc4c2c1)-c5ccco5 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | MRS 1220 Usage And Synthesis |
| Uses | MRS 1220 is a highly potent and selective human Adenosine A3-R antagonist. | | Definition | ChEBI: N-[9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide is a member of quinazolines. | | Biological Activity | A potent and highly selective antagonist at the human A 3 adenosine receptor (K i values are 0.65, 305, and 52 nM at hA 3 , rA 1 and rA 2A respectively. Displays an IC 50 value > 1 μ M for inhibition of binding to rat A 3 receptors). | | in vivo | MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2]. | Animal Model: | Eight, 8 week-old male Sprague-Dawley rats bearing C6 (GSCs)[2] | | Dosage: | 0.15 mg/kg/72 h | | Administration: | Administered by intraperitoneal inoculation, for fifteen days | | Result: | A reduction close to 80% and 90% in tumor volume compared to the vehicle-treated group at day ten and fifteen post-treatment, respectively.
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| | storage | Store at RT |
| | MRS 1220 Preparation Products And Raw materials |
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