| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Lipoxin A4-d5
CAS:1622429-53-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:Lipoxin A4-d5
Package:10ug Remarks: 见优宁维官网
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| Company Name: |
CHINA ISOTOPE CO., LIMITED
|
| Tel: |
02151600108 13062666369 |
| Email: |
info@isotopechem.com |
| Products Intro: |
Product Name:Lipoxin A4-d5
CAS:1622429-53-1
Purity:Purity: >=98% Package:10ug Remarks:CA10007737
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Lipoxin A4-d5
CAS:1622429-53-1
Purity:95% Package:10μg;25μg;50μg
|
|
| | IXAQOQZEOGMIQS-YUMLLTTFSA-N Basic information |
| | IXAQOQZEOGMIQS-YUMLLTTFSA-N Chemical Properties |
| storage temp. | Store at -80°C | | solubility | DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml |
| | IXAQOQZEOGMIQS-YUMLLTTFSA-N Usage And Synthesis |
| Uses | Lipoxin A4-d5 Sodium Salt is a labelled analog of Lipoxin A4 (L468775), which is a trihydroxy fatty acid produced through 15-HETE metabolism. | | Biological Activity | Lipoxin A4-d5 (LXA4-d5) contains five deuterium atoms at the 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of LXA4 by GC- or LC-mass spectrometry (MS). LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.1 LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.2,3,4 | | IC 50 | IL-8 | | References | 1.Serhan, C.N., Nicolaou, K.C., Webber, S.E., et al.Lipoxin A. Stereochemistry and biosynthesisJ. Biol. Chem.261(35)16340-16345(1986)
2.Serhan, C.N., Hamberg, M., and Samuelsson, B.Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytesProc. Natl. Acad. Sci. U.S.A.81(17)5335-5339(1984)
3.Ramstedt, U., Serhan, C.N., Nicolaou, K.C., et al.Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of actionJ. Immunol.138(1)266-270(1987)
4.Maddox, J.F., and Serhan, C.N.Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reductionJ. Exp. Med.183(1)137-146(1996) |
| | IXAQOQZEOGMIQS-YUMLLTTFSA-N Preparation Products And Raw materials |
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