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| | 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Basic information |
| | 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Chemical Properties |
| Melting point | 176-178 °C (dec.) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | color | White | | BRN | 4189683 | | Major Application | peptide synthesis | | InChI | 1S/C12H21NO4/c1-11(2,3)17-10(16)13-12(9(14)15)7-5-4-6-8-12/h4-8H2,1-3H3,(H,13,16)(H,14,15) | | InChIKey | URBHKVWOYIMKNO-UHFFFAOYSA-N | | SMILES | CC(C)(C)OC(=O)NC1(CCCCC1)C(O)=O | | CAS DataBase Reference | 115951-16-1(CAS DataBase Reference) |
| WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29225090 | | Storage Class | 13 - Non Combustible Solids |
| | 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | White powder | | Uses | peptide synthesis | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | 1-tert-butoxycarbonylamide cyclohexanecarboxylic acid was prepared as follows: sodium hydroxide solution (43 mL, 4 mol/L), THF (40 mL) and 1-aminocyclohexanecarboxylic acid (5.0 g, 34.96 mmol) were added to a round-bottomed flask, and di-tert-butyl dicarbonate (9.13 g, 41.96 mmol) was added to the reaction flask at 0 C. After dropwise addition was complete, the reaction system was After the dropwise addition, the reaction system was stirred at room temperature overnight. Water (100 mL) was added to the reaction system, acidified with hydrochloric acid (50 mL, 1 mol/L), then extracted with ethyl acetate (50 mL2), the organic phases were combined, and the organic phases were washed with saturated brine (100 mL2) and dried with anhydrous sodium sulfate. Filtered, evaporated the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate (V/V) = 4/1) to give the white solid title compound 1-tert-butoxycarbonylamide cyclohexanecarboxylic acid (7.3 g, 86%). |
| | 1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXANECARBOXYLIC ACID Preparation Products And Raw materials |
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