(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone

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Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone Basic information
Product Name:(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone
Synonyms:(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone;(1-butyl-4-hydroxy-1H-indol-3-yl)(naphthalen-1-yl)-methanone;Methanone, (1-butyl-4-hydroxy-1H-indol-3-yl)-1-naphthalenyl-
CAS:1307803-46-8
MF:C23H21NO2
MW:343.42
EINECS:
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Mol File:1307803-46-8.mol
(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone Structure
(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone Chemical Properties
solubility DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml
Safety Information
MSDS Information
(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone Usage And Synthesis
DescriptionJWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.1 JWH 073 is one of several synthetic CBs which have been included in smoking mixtures. JWH 073 4-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.2,3
References1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
3. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone Preparation Products And Raw materials
Tag:(1-butyl-4-hydroxyindol-3-yl)-naphthalen-1-ylmethanone(1307803-46-8) Related Product Information
JWH 018 5-hydroxyindole metabolite JWH 073 6-hydroxyindole metabolite (6-hydroxy-1-pentylindol-3-yl)-naphthalen-1-ylmethanone JWH 018 7-hydroxyindole metabolite JWH 073 2-hydroxyindole metabolite