| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
|
| | DM4-SPDP Basic information |
| Product Name: | DM4-SPDP | | Synonyms: | DM4-SPDP;Maytansine, N2'-deacetyl-N2'-[4-[[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]dithio]-4-methyl-1-oxopentyl]- | | CAS: | 2245698-48-8 | | MF: | C45H61ClN4O14S2 | | MW: | 981.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2245698-48-8.mol |  |
| | DM4-SPDP Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.82±0.70(Predicted) |
| | DM4-SPDP Usage And Synthesis |
| Uses | (R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates[1]. | | References | [1] Silvana T Tivadar, et al. Monoclonal Antibody Targeting Sialyl-di-Lewisa-Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential. Mol Cancer Ther. 2020 Mar;19(3):790-801. DOI:10.1158/1535-7163.MCT-19-0221 |
| | DM4-SPDP Preparation Products And Raw materials |
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Tag:DM4-SPDP(2245698-48-8)
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