D-Val-Phe-Lys chloromethyl ketone, dihydrochloride

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Company Name: Hangzhou Peptidego Biotech Co.,Ltd.  
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Company Name: Hangzhou Sinoda Pharmaceutical Technology Co. LTD  
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D-Val-Phe-Lys chloromethyl ketone, dihydrochloride Basic information
Product Name:D-Val-Phe-Lys chloromethyl ketone, dihydrochloride
Synonyms:PLASMIN INHIBITOR, 2HCL;valyl-phenylalanyl-lysine chloromethyl ketone;L-Phenylalaninamide, D-valyl-N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-;DVal-Phe-Lys-CMK;D-Val-Phe-Lys chloromethyl ketone, dihydrochloride
CAS:75590-17-9
MF:C21H33ClN4O3
MW:424.96
EINECS:
Product Categories:
Mol File:75590-17-9.mol
D-Val-Phe-Lys chloromethyl ketone, dihydrochloride Structure
D-Val-Phe-Lys chloromethyl ketone, dihydrochloride Chemical Properties
Boiling point 707.0±60.0 °C(Predicted)
density 1.160±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 5mg/mL
pka13.06±0.46(Predicted)
form lyophilized solid
color off-white
Sequence{d-Val}-Phe-Lys-{CMK}
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
D-Val-Phe-Lys chloromethyl ketone, dihydrochloride Usage And Synthesis
UsesD-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity[1].
Biological ActivityCell permeable: no', 'Primary Target
Human plasmin', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 100 pM for human plasmin
References[1] F Laube, et al. Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis. Br J Cancer. 2001 Sep 14;85(6):924-9. DOI:10.1054/bjoc.2001.2004
D-Val-Phe-Lys chloromethyl ketone, dihydrochloride Preparation Products And Raw materials
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H-D-Val-NH2 HCl N-Methyl-3-chloropropylamine hydrochloride (R)-(-)-2-Aminobutanamide hydrochloride, 97% PLASMIN (R)-(+)-1,2-Diaminopropane dihydrochloride H-D-ALA-GLY-NH2 HCL N-(1-methyl-2-oxopropyl)acetamide D-VAL-PHE-LYS CHLOROMETHYL KETONE, DIHYDROCHLORIDE H-GLY-PHE-NH2 HCL (2R)-2-Aminopropanamide hydrochloride