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Alfa Aesar |
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- 4-Chlorobenzhydrazide
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- $220.00
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2026-09-11
- CAS:536-40-3
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 500g;1kg;5kg;10kg;100kg;
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| | 4-Chlorobenzhydrazide Basic information |
| | 4-Chlorobenzhydrazide Chemical Properties |
| Melting point | 162-165 °C (lit.) | | Boiling point | 170.60°C | | density | 1.323 | | refractive index | 1.5618 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 12.09±0.10(Predicted) | | color | White to Almost white | | BRN | 511154 | | InChI | InChI=1S/C7H7ClN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11) | | InChIKey | PKBGHORNUFQAAW-UHFFFAOYSA-N | | SMILES | C(NN)(=O)C1=CC=C(Cl)C=C1 | | CAS DataBase Reference | 536-40-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29280000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Chlorobenzhydrazide Usage And Synthesis |
| Chemical Properties | white to light beige crystals, flakes or | | Uses | 4-Chlorobenzhydrazide has been used in preparation of:
- rod-shaped mesogenic hydrazide derivatives via Schotten-Baumann reaction with 4-n-alkoxybenzoyl chloride
- 4-methoxybenzaldehyde-4-chlorophenyl-1-carbonyl hydrazone
- 4-hydroxybenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
- 2-nitrobenzaldehyde-4-chlorophenyl-1-carbonylhydrazone
- benzaldehyde-4-chlorophenyl-1-carbonylhydrazone
| | General Description | Effect of acidic catalyst on the reaction of 4-chlorobenzhydrazide and β-naphthol in water has been investigated. | | Synthesis | General procedure for the synthesis of 4-chlorobenzoyl hydrazine from ethyl p-chlorobenzoate: hydrazine was synthesized conventionally using the one-pot method (30-58% yield). 10 mmol of ethyl p-chlorobenzoate was dissolved in 20 mL of ethanol. 2 mL of 3N sulfuric acid was added to the solution and the reaction mixture was refluxed for 6 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with solid NaHCO3 and filtered to remove excess NaHCO3. To the neutralized reaction mixture, 1.5 mL (3 mmol) of hydrazine monohydrate was added and refluxing was continued for 3-6 h to ensure complete reaction. The ethanol and unreacted hydrazine were evaporated to 1/3 of the original volume by distillation.The reaction mixture was cooled to room temperature, the product was collected by filtration and recrystallized from methanol to give pure 4-chlorobenzhydrazide crystals (see Supporting Information for specific data). | | Purification Methods | Crystallise it from H2O. [Beilstein 9 III 1368.] | | References | [1] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2755 - 2767
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 6014 - 6024
[3] Patent: CN106008390, 2016, A. Location in patent: Paragraph 0015
[4] Journal of Heterocyclic Chemistry, 1992, vol. 29, # 5, p. 1101 - 1109
[5] Oriental Journal of Chemistry, 2017, vol. 33, # 2, p. 971 - 978 |
| | 4-Chlorobenzhydrazide Preparation Products And Raw materials |
| Raw materials | methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate-->4-Chlorobenzoic acid-->Methyl 4-chlorobenzoate-->Ethyl 4-chlorobenzoate-->4-Chlorobenzamide-->Hydrazine hydrate-->Ethanol-->Water | | Preparation Products | Acemetacin-->4-Benzyl-5-(4-chloro-phenyl)-4H-[1,2,4]triazole-3-thiol-->4H-1,2,4-Triazole-4-acetic acid, 3-(4-chlorophenyl)-1,5-dihydro-5-oxo--->Ethyl 3-[2-(4-chlorobenzoyl)hydrazino]-3-iminopropanoate-->2-(Chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole-->2-(4-chlorophenyl)-5-Methyl-1,3,4-oxadiazole |
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